Damarin Block, which housed the Hansen Furniture Company, was located at 99 1/2 West Front Street.
T. M. Patterson Paper Box Company was located at 33-39 West Front Street.
The German Evangelical Church was located at the corner of Fifth (5th) and Washington Streets.
The First Presbyterian Church was located at the corner of Court and Third (3rd) Streets.
The Gilbert Grocery Company, started in 1832 by Martin B. Gilbert, was first located at 167 West Front Street. In 1898 this new building was built for the Gilbert business at 50-54 West Second (2nd). It was totally destroyed by fire in 1910.
The Harsha Flour Mills was located at 555 Eighth (8th) Street.
Wilhelmette Flats was located at the North East Corner of Fourth (4th) and Court Steets. John Wilhelm built this building and operated the Wilhelm Opera House on the top floor from 1870 until 1899. It was later made into Wilhelmette Flast apartments.
The Hotel Grimes was located on the southeast corner of Second (2nd) and Gay Streets. Built by H. S. Grimes, it was a famous building in Portsmouth as it was the first "flat" building, meaning the roof was void of any irregularities.(Portsmouth Daily Times, July 27, 1907) It had 43 rooms and was rented by the Y.W.C.A. in 1912. It became Grimes Apartments from 1922 to 1966 when it was razed for the expansion of Ohio University Portsmouth Branch, later Shawnee Community College.
The Hotel Washington, at 500 Second (2nd) Street, was known for its beautiful entrance way. In about 1980 it became part of the Riverview Retirement Center along with the Biggs House.
The Gallia Street High School was located at northwest Corner of Gallia and Waller Streets. After 1909 plans were drawn up for a new school building because there were too many students and not enough room. Students attended the old school until 1912 when the new one was constructed on the property of the Davis High School building after it was razed.
Marting Brothers Company was located at 515 Chillicothe Street and 12-16 West Sixth Street. At Marting's, one could find dry goods, millinery, cloaks, carpets, shoes, and more.