According to the Scioto County Auditor, the building was built in 1900. In the early 1900's, it was used as home and had numerous residence. From the 1930's and onward, it housed various commercial and retail businesses. Today, it is the home of the Belle Le Femme' Beauty Salon.
From the early 1900's to around the earl 1930's this building was Joseph Brown Clothing. In 1939 it became Nan L. Murphy Women's Clothing. From 1964 to around 2005 it was The Record Shop.
From 1922 to 1925 this building was the Portsmouth Auto Supply Company. From 1928 to 1944 the building was used for various retail stores. From 1993 to 2001 it was the Portsmouth Eagles Club and Aerie. In 2005 it became Richard Noggins Restaurant. Razed in May, 2023.
This building was formerly RT Staker Enterprises LLC and was built around 1900. It has gone through several ownership changes since 1950, all of which were in the Staker family. In January 1950, James Staker and R. Thomas were the owners. In 2011, James Staker become the sole owner. Throughout the 1900's, it was home to various commercial businesses.
According to the Scioto County Auditor, this building was built in 1900. From around 1914 to 1977, this building was the Security Central National Bank of Portsmouth. In 1978, it became the Southern Ohio Museum and Cultural Center. It remains this today.